Efficient modification of PAMAM G1 dendrimer surface with β-cyclodextrin units by CuAAC: impact on the water solubility and cytotoxicity

The toxicity of the poly(amidoamine) dendrimers (PAMAM) caused by the peripheral amino groups has been a limitation for their use as drug carriers in clinical applications. In this work, we completely modified the periphery of PAMAM dendrimer generation 1 (PAMAM G1) with β-cyclodextrin (β-CD) units...

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Detalles Bibliográficos
Autores principales: Sorroza-Martínez, Kendra, González-Méndez, Israel, Martínez-Serrano, Ricardo D., Solano, José D., Ruiu, Andrea, Illescas, Javier, Zhu, Xiao Xia, Rivera, Ernesto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055266/
https://www.ncbi.nlm.nih.gov/pubmed/35518581
http://dx.doi.org/10.1039/d0ra02574g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055266/
https://www.ncbi.nlm.nih.gov/pubmed/35518581
http://dx.doi.org/10.1039/d0ra02574g

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