Novel huperzine A based NMDA antagonists: insights from molecular docking, ADME/T and molecular dynamics simulation studies

Huperzine A (HupA) is an alkaloidal natural product and drug isolated from Chinese herb Huperzia serrata, which is a potent selective anticholinesterase inhibitor. HupA has symptomatic, cognitive-enhancing and protective effect on neurons against amyloid beta-induced oxidative injury and antagonizin...

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Detalles Bibliográficos
Autores principales: Sigalapalli, Dilep Kumar, Rangaswamy, Raghu, Tangellamudi, Neelima D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055280/
https://www.ncbi.nlm.nih.gov/pubmed/35518623
http://dx.doi.org/10.1039/d0ra00722f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055280/
https://www.ncbi.nlm.nih.gov/pubmed/35518623
http://dx.doi.org/10.1039/d0ra00722f

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