Residue-based propensity of aggregation in the Tau amyloidogenic hexapeptides AcPHF6* and AcPHF6

In Alzheimer's disease and related tauopathies, the aggregation of microtubule-associated protein, Tau, into fibrils occurs via the interaction of two hexapeptide motifs PHF* (275)VQIINK(280) and PHF (306)VQIVYK(311) as β-sheets. To understand the role of the constituent amino acids of PHF and...

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Detalles Bibliográficos
Autores principales: Dangi, Abha, Balmik, Abhishek Ankur, Ghorpade, Archana Kisan, Gorantla, Nalini Vijay, Sonawane, Shweta Kishor, Chinnathambi, Subashchandrabose, Marelli, Udaya Kiran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055513/
https://www.ncbi.nlm.nih.gov/pubmed/35516938
http://dx.doi.org/10.1039/d0ra03809a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055513/
https://www.ncbi.nlm.nih.gov/pubmed/35516938
http://dx.doi.org/10.1039/d0ra03809a

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