Cargando…
Residue-based propensity of aggregation in the Tau amyloidogenic hexapeptides AcPHF6* and AcPHF6
In Alzheimer's disease and related tauopathies, the aggregation of microtubule-associated protein, Tau, into fibrils occurs via the interaction of two hexapeptide motifs PHF* (275)VQIINK(280) and PHF (306)VQIVYK(311) as β-sheets. To understand the role of the constituent amino acids of PHF and...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055513/ https://www.ncbi.nlm.nih.gov/pubmed/35516938 http://dx.doi.org/10.1039/d0ra03809a |