Effect of C-terminus amidation of Aβ(39–42) fragment derived peptides as potential inhibitors of Aβ aggregation

The C-terminus fragment (Val-Val-Ile-Ala) of amyloid-β is reported to inhibit the aggregation of the parent peptide. In an attempt to investigate the effect of sequential amino-acid scan and C-terminus amidation on the biological profile of the lead sequence, a series of tetrapeptides were synthesiz...

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Detalles Bibliográficos
Autores principales: Kapadia, Akshay, Patel, Aesan, Sharma, Krishna K., Maurya, Indresh Kumar, Singh, Varinder, Khullar, Madhu, Jain, Rahul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055537/
https://www.ncbi.nlm.nih.gov/pubmed/35515767
http://dx.doi.org/10.1039/d0ra04788k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055537/
https://www.ncbi.nlm.nih.gov/pubmed/35515767
http://dx.doi.org/10.1039/d0ra04788k

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