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Effect of C-terminus amidation of Aβ(39–42) fragment derived peptides as potential inhibitors of Aβ aggregation
The C-terminus fragment (Val-Val-Ile-Ala) of amyloid-β is reported to inhibit the aggregation of the parent peptide. In an attempt to investigate the effect of sequential amino-acid scan and C-terminus amidation on the biological profile of the lead sequence, a series of tetrapeptides were synthesiz...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055537/ https://www.ncbi.nlm.nih.gov/pubmed/35515767 http://dx.doi.org/10.1039/d0ra04788k |