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Demographic Profile and Prescribing Patterns of Anti-epileptic Drugs in Indian Epilepsy Patients: Electronic Medical Record-Based Nation-Wide Retrospective Cohort Study

The aim of this study was to provide real-world data on clinical characteristics, risk factors, and treatment patterns in Indian patients with epilepsy. Electronic medical record (EMR) data of patients diagnosed with epilepsy between January 2001 and December 2019, which included demographics, diagn...

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Autores principales: Bansal, Atmaram, Shah, Shalin, Kumar, Shiva, Haldar, Amit, B.K, Madhusudan, Brahma, Smita, Gaurav, Kumar, Pinto, Colette, Mane, Amey, Shah, Snehal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055561/
https://www.ncbi.nlm.nih.gov/pubmed/35505726
http://dx.doi.org/10.7759/cureus.23676
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author Bansal, Atmaram
Shah, Shalin
Kumar, Shiva
Haldar, Amit
B.K, Madhusudan
Brahma, Smita
Gaurav, Kumar
Pinto, Colette
Mane, Amey
Shah, Snehal
author_facet Bansal, Atmaram
Shah, Shalin
Kumar, Shiva
Haldar, Amit
B.K, Madhusudan
Brahma, Smita
Gaurav, Kumar
Pinto, Colette
Mane, Amey
Shah, Snehal
author_sort Bansal, Atmaram
collection PubMed
description The aim of this study was to provide real-world data on clinical characteristics, risk factors, and treatment patterns in Indian patients with epilepsy. Electronic medical record (EMR) data of patients diagnosed with epilepsy between January 2001 and December 2019, which included demographics, diagnosis, anti-epileptic drug usage, and underlying risk factors were evaluated. The majority of patients were between the age group of 18 and 55 years (n=3,186), with males accounting for 62% and the remaining 38% being females. Further, the most common comorbidity was hypertension (23.3%, n=1,470), followed by diabetes mellitus (10.8%, n=683) and depression (9.4%, n=597). The most prevalent form of epilepsy was focal epilepsy (n=5,141 81.4%), followed by generalized epilepsy (n=601). Focal epilepsy was most prevalent in males (62%, n=3,167) and most common in the age group of 18-55 years (50.3%, n=2588). Anti-epileptic drug (AED) usage data from 6,318 patients showed that the most commonly prescribed AED alone or in combination for both focal and generalized epilepsy was levetiracetam (41.8%, n= 2645). Data collected from this study are aligned but do not completely agree with the Guidelines for the Management of Epilepsy in India (GEMIND). This affirms treatment initiation with AED monotherapy; however, the treatment choices do not necessarily follow the recommended guidelines to select conventional AEDs, at low strengths, at initiation.
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spelling pubmed-90555612022-05-02 Demographic Profile and Prescribing Patterns of Anti-epileptic Drugs in Indian Epilepsy Patients: Electronic Medical Record-Based Nation-Wide Retrospective Cohort Study Bansal, Atmaram Shah, Shalin Kumar, Shiva Haldar, Amit B.K, Madhusudan Brahma, Smita Gaurav, Kumar Pinto, Colette Mane, Amey Shah, Snehal Cureus Internal Medicine The aim of this study was to provide real-world data on clinical characteristics, risk factors, and treatment patterns in Indian patients with epilepsy. Electronic medical record (EMR) data of patients diagnosed with epilepsy between January 2001 and December 2019, which included demographics, diagnosis, anti-epileptic drug usage, and underlying risk factors were evaluated. The majority of patients were between the age group of 18 and 55 years (n=3,186), with males accounting for 62% and the remaining 38% being females. Further, the most common comorbidity was hypertension (23.3%, n=1,470), followed by diabetes mellitus (10.8%, n=683) and depression (9.4%, n=597). The most prevalent form of epilepsy was focal epilepsy (n=5,141 81.4%), followed by generalized epilepsy (n=601). Focal epilepsy was most prevalent in males (62%, n=3,167) and most common in the age group of 18-55 years (50.3%, n=2588). Anti-epileptic drug (AED) usage data from 6,318 patients showed that the most commonly prescribed AED alone or in combination for both focal and generalized epilepsy was levetiracetam (41.8%, n= 2645). Data collected from this study are aligned but do not completely agree with the Guidelines for the Management of Epilepsy in India (GEMIND). This affirms treatment initiation with AED monotherapy; however, the treatment choices do not necessarily follow the recommended guidelines to select conventional AEDs, at low strengths, at initiation. Cureus 2022-03-31 /pmc/articles/PMC9055561/ /pubmed/35505726 http://dx.doi.org/10.7759/cureus.23676 Text en Copyright © 2022, Bansal et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Bansal, Atmaram
Shah, Shalin
Kumar, Shiva
Haldar, Amit
B.K, Madhusudan
Brahma, Smita
Gaurav, Kumar
Pinto, Colette
Mane, Amey
Shah, Snehal
Demographic Profile and Prescribing Patterns of Anti-epileptic Drugs in Indian Epilepsy Patients: Electronic Medical Record-Based Nation-Wide Retrospective Cohort Study
title Demographic Profile and Prescribing Patterns of Anti-epileptic Drugs in Indian Epilepsy Patients: Electronic Medical Record-Based Nation-Wide Retrospective Cohort Study
title_full Demographic Profile and Prescribing Patterns of Anti-epileptic Drugs in Indian Epilepsy Patients: Electronic Medical Record-Based Nation-Wide Retrospective Cohort Study
title_fullStr Demographic Profile and Prescribing Patterns of Anti-epileptic Drugs in Indian Epilepsy Patients: Electronic Medical Record-Based Nation-Wide Retrospective Cohort Study
title_full_unstemmed Demographic Profile and Prescribing Patterns of Anti-epileptic Drugs in Indian Epilepsy Patients: Electronic Medical Record-Based Nation-Wide Retrospective Cohort Study
title_short Demographic Profile and Prescribing Patterns of Anti-epileptic Drugs in Indian Epilepsy Patients: Electronic Medical Record-Based Nation-Wide Retrospective Cohort Study
title_sort demographic profile and prescribing patterns of anti-epileptic drugs in indian epilepsy patients: electronic medical record-based nation-wide retrospective cohort study
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055561/
https://www.ncbi.nlm.nih.gov/pubmed/35505726
http://dx.doi.org/10.7759/cureus.23676
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