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Conformational dynamics of superoxide dismutase (SOD1) in osmolytes: a molecular dynamics simulation study
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease caused by the misfolding of Cu, Zn superoxide dismutase (SOD1). Several earlier studies have shown that monomeric apo SOD1 undergoes significant local unfolding dynamics and is the predecessor for aggregation. Here, we ha...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Royal Society of Chemistry
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055598/ https://www.ncbi.nlm.nih.gov/pubmed/35516947 http://dx.doi.org/10.1039/d0ra02151b |