Novel drug isolated from mistletoe (1E,4E)-1,7-bis(4-hydroxyphenyl)hepta-1,4-dien-3-one for potential treatment of various cancers: synthesis, pharmacokinetics and pharmacodynamics

(1E,4E)-1,7-Bis(4-hydroxyphenyl)hepta-1,4-dien-3-one (DHDK) is a novel curcuminoid analogue isolated from mistletoe. DHDK exhibits better anti-tumour activity, higher bioavailability and superior stability than curcumin. DHDK is difficult to isolate from Viscum coloratum, but it can be synthesised....

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Detalles Bibliográficos
Autores principales: Hong, Jing, Meng, Lin, Yu, Peipei, Zhou, Ceng, Zhang, Zhaoyan, Yu, Zhiguo, Qin, Feng, Zhao, Yunli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055608/
https://www.ncbi.nlm.nih.gov/pubmed/35516963
http://dx.doi.org/10.1039/d0ra03674a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055608/
https://www.ncbi.nlm.nih.gov/pubmed/35516963
http://dx.doi.org/10.1039/d0ra03674a

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