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Novel drug isolated from mistletoe (1E,4E)-1,7-bis(4-hydroxyphenyl)hepta-1,4-dien-3-one for potential treatment of various cancers: synthesis, pharmacokinetics and pharmacodynamics

(1E,4E)-1,7-Bis(4-hydroxyphenyl)hepta-1,4-dien-3-one (DHDK) is a novel curcuminoid analogue isolated from mistletoe. DHDK exhibits better anti-tumour activity, higher bioavailability and superior stability than curcumin. DHDK is difficult to isolate from Viscum coloratum, but it can be synthesised....

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Detalles Bibliográficos
Autores principales:	Hong, Jing, Meng, Lin, Yu, Peipei, Zhou, Ceng, Zhang, Zhaoyan, Yu, Zhiguo, Qin, Feng, Zhao, Yunli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055608/ https://www.ncbi.nlm.nih.gov/pubmed/35516963 http://dx.doi.org/10.1039/d0ra03674a

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