Visible light-induced photocatalytic C–H ethoxycarbonylmethylation of imidazoheterocycles with ethyl diazoacetate

A visible light-mediated regioselective C3-ethoxycarbonylmethylation of imidazopyridines with ethyl diazoacetate (EDA) was achieved under mild reaction conditions. In contrast to the carbene precursors from α-diazoester a first C3-ethoxycarbonylmethylation of imidazopyridines via a radical intermedi...

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Autores principales: Bhattacharjee, Suvam, Laru, Sudip, Samanta, Sadhanendu, Singsardar, Mukta, Hajra, Alakananda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055643/
https://www.ncbi.nlm.nih.gov/pubmed/35519122
http://dx.doi.org/10.1039/d0ra05795a
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author Bhattacharjee, Suvam
Laru, Sudip
Samanta, Sadhanendu
Singsardar, Mukta
Hajra, Alakananda
author_facet Bhattacharjee, Suvam
Laru, Sudip
Samanta, Sadhanendu
Singsardar, Mukta
Hajra, Alakananda
author_sort Bhattacharjee, Suvam
collection PubMed
description A visible light-mediated regioselective C3-ethoxycarbonylmethylation of imidazopyridines with ethyl diazoacetate (EDA) was achieved under mild reaction conditions. In contrast to the carbene precursors from α-diazoester a first C3-ethoxycarbonylmethylation of imidazopyridines via a radical intermediate has been established. The present methodology provides a concise route to access pharmacologically useful esters with wide functional group tolerance in high yields.
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spelling pubmed-90556432022-05-04 Visible light-induced photocatalytic C–H ethoxycarbonylmethylation of imidazoheterocycles with ethyl diazoacetate Bhattacharjee, Suvam Laru, Sudip Samanta, Sadhanendu Singsardar, Mukta Hajra, Alakananda RSC Adv Chemistry A visible light-mediated regioselective C3-ethoxycarbonylmethylation of imidazopyridines with ethyl diazoacetate (EDA) was achieved under mild reaction conditions. In contrast to the carbene precursors from α-diazoester a first C3-ethoxycarbonylmethylation of imidazopyridines via a radical intermediate has been established. The present methodology provides a concise route to access pharmacologically useful esters with wide functional group tolerance in high yields. The Royal Society of Chemistry 2020-07-28 /pmc/articles/PMC9055643/ /pubmed/35519122 http://dx.doi.org/10.1039/d0ra05795a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Bhattacharjee, Suvam
Laru, Sudip
Samanta, Sadhanendu
Singsardar, Mukta
Hajra, Alakananda
Visible light-induced photocatalytic C–H ethoxycarbonylmethylation of imidazoheterocycles with ethyl diazoacetate
title Visible light-induced photocatalytic C–H ethoxycarbonylmethylation of imidazoheterocycles with ethyl diazoacetate
title_full Visible light-induced photocatalytic C–H ethoxycarbonylmethylation of imidazoheterocycles with ethyl diazoacetate
title_fullStr Visible light-induced photocatalytic C–H ethoxycarbonylmethylation of imidazoheterocycles with ethyl diazoacetate
title_full_unstemmed Visible light-induced photocatalytic C–H ethoxycarbonylmethylation of imidazoheterocycles with ethyl diazoacetate
title_short Visible light-induced photocatalytic C–H ethoxycarbonylmethylation of imidazoheterocycles with ethyl diazoacetate
title_sort visible light-induced photocatalytic c–h ethoxycarbonylmethylation of imidazoheterocycles with ethyl diazoacetate
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055643/
https://www.ncbi.nlm.nih.gov/pubmed/35519122
http://dx.doi.org/10.1039/d0ra05795a
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