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The selection of highly specific and selective aptamers using modified SELEX and their use in process analytical techniques for Lucentis bioproduction
Aptamers for Lucentis were selected using 10 rounds of a modified and highly stringent SELEX process. Affinity column chromatography was used for the binding, partitioning, and elution steps, and the regeneration of ssDNA was performed via asymmetric PCR in the SELEX process. The interaction of apta...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055848/ https://www.ncbi.nlm.nih.gov/pubmed/35520059 http://dx.doi.org/10.1039/d0ra03542d |