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Genome‐scale screening in a rat haploid system identifies Thop1 as a modulator of pluripotency exit

OBJECTIVES: The rats are crucial animal models for the basic medical researches. Rat embryonic stem cells (ESCs), which are widely studied, can self‐renew and exhibit pluripotency in long‐term culture, but the mechanism underlying how they exit pluripotency remains obscure. To investigate the key mo...

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Detalles Bibliográficos
Autores principales: Xu, Mei, Zhao, Yiding, Zhang, Wenhao, Geng, Mengyang, Liu, Qian, Gao, Qian, Shuai, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055895/
https://www.ncbi.nlm.nih.gov/pubmed/35274380
http://dx.doi.org/10.1111/cpr.13209