Regioselective O/C phosphorylation of α-chloroketones: a general method for the synthesis of enol phosphates and β-ketophosphonates via Perkow/Arbuzov reaction

A regioselective O/C phosphorylation of α-chloroketones with trialkyl phosphites was performed for the first time, which employed solvent-free Perkow reaction and NaI-assisted Arbuzov reaction under mild conditions respectively. Versatile enol phosphates were prepared in good to excellent yields as...

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Autores principales: Cao, Yuepeng, Gao, Zhenhua, Li, Junchen, Bi, Xiaojing, Yuan, Ling, Pei, Chengxin, Guo, Yongbiao, Shi, Enxue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055934/
https://www.ncbi.nlm.nih.gov/pubmed/35521103
http://dx.doi.org/10.1039/d0ra05140c
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author Cao, Yuepeng
Gao, Zhenhua
Li, Junchen
Bi, Xiaojing
Yuan, Ling
Pei, Chengxin
Guo, Yongbiao
Shi, Enxue
author_facet Cao, Yuepeng
Gao, Zhenhua
Li, Junchen
Bi, Xiaojing
Yuan, Ling
Pei, Chengxin
Guo, Yongbiao
Shi, Enxue
author_sort Cao, Yuepeng
collection PubMed
description A regioselective O/C phosphorylation of α-chloroketones with trialkyl phosphites was performed for the first time, which employed solvent-free Perkow reaction and NaI-assisted Arbuzov reaction under mild conditions respectively. Versatile enol phosphates were prepared in good to excellent yields as well as β-ketophosphinates.
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spelling pubmed-90559342022-05-04 Regioselective O/C phosphorylation of α-chloroketones: a general method for the synthesis of enol phosphates and β-ketophosphonates via Perkow/Arbuzov reaction Cao, Yuepeng Gao, Zhenhua Li, Junchen Bi, Xiaojing Yuan, Ling Pei, Chengxin Guo, Yongbiao Shi, Enxue RSC Adv Chemistry A regioselective O/C phosphorylation of α-chloroketones with trialkyl phosphites was performed for the first time, which employed solvent-free Perkow reaction and NaI-assisted Arbuzov reaction under mild conditions respectively. Versatile enol phosphates were prepared in good to excellent yields as well as β-ketophosphinates. The Royal Society of Chemistry 2020-08-11 /pmc/articles/PMC9055934/ /pubmed/35521103 http://dx.doi.org/10.1039/d0ra05140c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Cao, Yuepeng
Gao, Zhenhua
Li, Junchen
Bi, Xiaojing
Yuan, Ling
Pei, Chengxin
Guo, Yongbiao
Shi, Enxue
Regioselective O/C phosphorylation of α-chloroketones: a general method for the synthesis of enol phosphates and β-ketophosphonates via Perkow/Arbuzov reaction
title Regioselective O/C phosphorylation of α-chloroketones: a general method for the synthesis of enol phosphates and β-ketophosphonates via Perkow/Arbuzov reaction
title_full Regioselective O/C phosphorylation of α-chloroketones: a general method for the synthesis of enol phosphates and β-ketophosphonates via Perkow/Arbuzov reaction
title_fullStr Regioselective O/C phosphorylation of α-chloroketones: a general method for the synthesis of enol phosphates and β-ketophosphonates via Perkow/Arbuzov reaction
title_full_unstemmed Regioselective O/C phosphorylation of α-chloroketones: a general method for the synthesis of enol phosphates and β-ketophosphonates via Perkow/Arbuzov reaction
title_short Regioselective O/C phosphorylation of α-chloroketones: a general method for the synthesis of enol phosphates and β-ketophosphonates via Perkow/Arbuzov reaction
title_sort regioselective o/c phosphorylation of α-chloroketones: a general method for the synthesis of enol phosphates and β-ketophosphonates via perkow/arbuzov reaction
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055934/
https://www.ncbi.nlm.nih.gov/pubmed/35521103
http://dx.doi.org/10.1039/d0ra05140c
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