Design, synthesis and biological evaluation of new 2-aminothiazole scaffolds as phosphodiesterase type 5 regulators and COX-1/COX-2 inhibitors

A new series of 2-aminothiazole derivatives was designed and prepared as phosphodiesterase type 5 (PDE5) regulators and COX-1/COX-2 inhibitors. The screening of the synthesized compounds for PDE5 activity was carried out using sildenafil as a reference drug. Strikingly, compounds 23a and 23c were fo...

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Detalles Bibliográficos
Autores principales: Hussein, Abdel Haleem M., Khames, Ahmed A., El-Adasy, Abu-Bakr A., Atalla, Ahmed A., Abdel-Rady, Mohamed, Hassan, Mohamed I. A., Nemr, Mohamed T. M., Elshaier, Yaseen A. A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056166/
https://www.ncbi.nlm.nih.gov/pubmed/35518254
http://dx.doi.org/10.1039/d0ra05561a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056166/
https://www.ncbi.nlm.nih.gov/pubmed/35518254
http://dx.doi.org/10.1039/d0ra05561a

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