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Design, synthesis and biological evaluation of new 2-aminothiazole scaffolds as phosphodiesterase type 5 regulators and COX-1/COX-2 inhibitors

A new series of 2-aminothiazole derivatives was designed and prepared as phosphodiesterase type 5 (PDE5) regulators and COX-1/COX-2 inhibitors. The screening of the synthesized compounds for PDE5 activity was carried out using sildenafil as a reference drug. Strikingly, compounds 23a and 23c were fo...

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Detalles Bibliográficos
Autores principales:	Hussein, Abdel Haleem M., Khames, Ahmed A., El-Adasy, Abu-Bakr A., Atalla, Ahmed A., Abdel-Rady, Mohamed, Hassan, Mohamed I. A., Nemr, Mohamed T. M., Elshaier, Yaseen A. A. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056166/ https://www.ncbi.nlm.nih.gov/pubmed/35518254 http://dx.doi.org/10.1039/d0ra05561a

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