Synthesis and biological evaluation of fluoro-substituted spiro-isoxazolines as potential anti-viral and anti-cancer agents

Electrophilic fluorine-mediated dearomative spirocyclization has been developed to synthesize a range of fluoro-substituted spiro-isoxazoline ethers and lactones. The in vitro biological assays of synthesized compounds were probed for anti-viral activity against human cytomegalovirus (HCMV) and cyto...

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Detalles Bibliográficos
Autores principales: Das, Prasanta, Boone, Sarah, Mitra, Dipanwita, Turner, Lindsay, Tandon, Ritesh, Raucher, Drazen, Hamme, Ashton T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056317/
https://www.ncbi.nlm.nih.gov/pubmed/35518245
http://dx.doi.org/10.1039/d0ra06148d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056317/
https://www.ncbi.nlm.nih.gov/pubmed/35518245
http://dx.doi.org/10.1039/d0ra06148d

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