A [3 + 2] cycloaddition/C-arylation of isatin N,N′-cyclic azomethine imine 1,3-dipole with arynes

A [3 + 2] annulation/C-arylation of isatin N,N′-cyclic azomethine imine 1,3-dipole 1 with in situ generated arynes has been established for the synthesis of 3,3-disubstituted oxindole scaffolds. These highly functionalized scaffolds were assembled in moderate yields (up to 85% yield). The novel spir...

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Detalles Bibliográficos
Autores principales: Jin, Qiaomei, Zhang, Dongjian, Zhang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056323/
https://www.ncbi.nlm.nih.gov/pubmed/35516012
http://dx.doi.org/10.1039/d0ra06404a
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author Jin, Qiaomei
Zhang, Dongjian
Zhang, Jian
author_facet Jin, Qiaomei
Zhang, Dongjian
Zhang, Jian
author_sort Jin, Qiaomei
collection PubMed
description A [3 + 2] annulation/C-arylation of isatin N,N′-cyclic azomethine imine 1,3-dipole 1 with in situ generated arynes has been established for the synthesis of 3,3-disubstituted oxindole scaffolds. These highly functionalized scaffolds were assembled in moderate yields (up to 85% yield). The novel spirooxindole scaffolds displayed moderate antitumor activities, which represented promising lead compounds for antitumor drug discovery.
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spelling pubmed-90563232022-05-04 A [3 + 2] cycloaddition/C-arylation of isatin N,N′-cyclic azomethine imine 1,3-dipole with arynes Jin, Qiaomei Zhang, Dongjian Zhang, Jian RSC Adv Chemistry A [3 + 2] annulation/C-arylation of isatin N,N′-cyclic azomethine imine 1,3-dipole 1 with in situ generated arynes has been established for the synthesis of 3,3-disubstituted oxindole scaffolds. These highly functionalized scaffolds were assembled in moderate yields (up to 85% yield). The novel spirooxindole scaffolds displayed moderate antitumor activities, which represented promising lead compounds for antitumor drug discovery. The Royal Society of Chemistry 2020-08-19 /pmc/articles/PMC9056323/ /pubmed/35516012 http://dx.doi.org/10.1039/d0ra06404a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Jin, Qiaomei
Zhang, Dongjian
Zhang, Jian
A [3 + 2] cycloaddition/C-arylation of isatin N,N′-cyclic azomethine imine 1,3-dipole with arynes
title A [3 + 2] cycloaddition/C-arylation of isatin N,N′-cyclic azomethine imine 1,3-dipole with arynes
title_full A [3 + 2] cycloaddition/C-arylation of isatin N,N′-cyclic azomethine imine 1,3-dipole with arynes
title_fullStr A [3 + 2] cycloaddition/C-arylation of isatin N,N′-cyclic azomethine imine 1,3-dipole with arynes
title_full_unstemmed A [3 + 2] cycloaddition/C-arylation of isatin N,N′-cyclic azomethine imine 1,3-dipole with arynes
title_short A [3 + 2] cycloaddition/C-arylation of isatin N,N′-cyclic azomethine imine 1,3-dipole with arynes
title_sort [3 + 2] cycloaddition/c-arylation of isatin n,n′-cyclic azomethine imine 1,3-dipole with arynes
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056323/
https://www.ncbi.nlm.nih.gov/pubmed/35516012
http://dx.doi.org/10.1039/d0ra06404a
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