Deubiquitylase OTUD3 prevents Parkinson’s disease through stabilizing iron regulatory protein 2

Iron deposits are neuropathological hallmark of Parkinson’s disease (PD). Iron regulatory protein 2 (IRP2) is a key factor in regulating brain iron homeostasis. Although two ubiquitin ligases that promote IRP2 degradation have been identified, the deubiquitylase for stabilization of IRP2 in PD remai...

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Detalles Bibliográficos
Autores principales: Jia, Fengju, Li, Hongchang, Jiao, Qian, Li, Chaonan, Fu, Lin, Cui, Chunping, Jiang, Hong, Zhang, Lingqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056525/
https://www.ncbi.nlm.nih.gov/pubmed/35490179
http://dx.doi.org/10.1038/s41419-022-04704-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056525/
https://www.ncbi.nlm.nih.gov/pubmed/35490179
http://dx.doi.org/10.1038/s41419-022-04704-0

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