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Aptamer loaded superparamagnetic beads for selective capturing and gentle release of activated protein C

Activated protein C (APC) is a serine protease with anticoagulant and cytoprotective activities which make it an attractive target for diagnostic and therapeutic applications. In this work, we present one-step activation of APC from a commercial source of protein C (PC, Ceprotin) followed by rapid a...

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Detalles Bibliográficos
Autores principales: Hamedani, Nasim Shahidi, Happich, Felix Lucian, Klein, Eva-Maria, Rühl, Heiko, Mayer, Günter, Oldenburg, Johannes, Müller, Jens, Pötzsch, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056527/
https://www.ncbi.nlm.nih.gov/pubmed/35490167
http://dx.doi.org/10.1038/s41598-022-11198-5