Elaborating piperazinyl-furopyrimidine based scaffolds as phosphoinositol-3-kinase enzyme alpha (PI3Kα) inhibitors to combat pancreatic cancer

Phosphoinositol-3-kinase enzyme (PI3K) plays a crucial role in driving oncogenic growth in various mammalian cells, particularly pancreatic cells. In the current study a series of novel furo[2,3-d]pyrimidine based-compounds were designed and synthesized as potential PI3K-α inhibitors. In accordance...

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Detalles Bibliográficos
Autores principales: Mansour, Mai A., Lasheen, Deena S., Gaber, Hatem M., Abouzid, Khaled A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056536/
https://www.ncbi.nlm.nih.gov/pubmed/35518146
http://dx.doi.org/10.1039/d0ra06428a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056536/
https://www.ncbi.nlm.nih.gov/pubmed/35518146
http://dx.doi.org/10.1039/d0ra06428a

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