A novel route to a chiral building block for the preparation of cyclopentenyl carbocyclic nucleosides. Synthesis and anticancer activity of enantiomeric neplanocins A

The synthesis of both enantiomers of 3-[(tert-butyldimethylsilyl)oxy]methyl-4,5-O-isopropylidenecyclopent-2-en-1-ol was accomplished in six steps based on optically inactive dimethyl meso-tartrate. This key intermediate in the synthesis of cyclopentenyl carbocyclic nucleosides was subsequently appli...

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Detalles Bibliográficos
Autores principales: Łukasik, Beata, Mikina, Maciej, Mikołajczyk, Marian, Pawłowska, Róża, Żurawiński, Remigiusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056547/
https://www.ncbi.nlm.nih.gov/pubmed/35518147
http://dx.doi.org/10.1039/d0ra06394k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056547/
https://www.ncbi.nlm.nih.gov/pubmed/35518147
http://dx.doi.org/10.1039/d0ra06394k

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