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Reporter-recruiting bifunctional aptasensor for bioluminescent analytical assays

We report a novel bioluminescent aptasensor, which consists of 2′-F-RNA aptamer modules joined into a bi-specific aptamer construct. One aptamer module binds the analyte, then after structural rearrangement the second module recruits non-covalently Ca(2+)-dependent photoprotein obelin from the solut...

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Bibliographic Details
Main Authors: Davydova, Anna, Krasitskaya, Vasilisa, Vorobjev, Pavel, Timoshenko, Valentina, Tupikin, Alexey, Kabilov, Marsel, Frank, Ludmila, Venyaminova, Alya, Vorobyeva, Mariya
Format: Online Article Text
Language:English
Published: The Royal Society of Chemistry 2020
Subjects:
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056652/
https://www.ncbi.nlm.nih.gov/pubmed/35516485
http://dx.doi.org/10.1039/d0ra05117a