Synthesis and properties of DNA oligomers containing stereopure phosphorothioate linkages and C-5 modified deoxyuridine derivatives

Phosphorothioate (PS) modification, where a non-bridging oxygen atom in a phosphodiester linkage is replaced by a sulfur atom, is widely used to improve the properties of nucleic acid drugs. Each PS linkage can be found in two stereoisomers, Rp and Sp. Since one non-bridging oxygen or sulfur atom in...

Descripción completa

Detalles Bibliográficos
Autores principales: Hara, Rintaro Iwata, Yoshino, Reijiro, Nukaga, Yohei, Maeda, Yusuke, Sato, Kazuki, Wada, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056737/
https://www.ncbi.nlm.nih.gov/pubmed/35519073
http://dx.doi.org/10.1039/d0ra06970a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056737/
https://www.ncbi.nlm.nih.gov/pubmed/35519073
http://dx.doi.org/10.1039/d0ra06970a

Ejemplares similares