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Synthesis and properties of DNA oligomers containing stereopure phosphorothioate linkages and C-5 modified deoxyuridine derivatives

Phosphorothioate (PS) modification, where a non-bridging oxygen atom in a phosphodiester linkage is replaced by a sulfur atom, is widely used to improve the properties of nucleic acid drugs. Each PS linkage can be found in two stereoisomers, Rp and Sp. Since one non-bridging oxygen or sulfur atom in...

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Detalles Bibliográficos
Autores principales:	Hara, Rintaro Iwata, Yoshino, Reijiro, Nukaga, Yohei, Maeda, Yusuke, Sato, Kazuki, Wada, Takeshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056737/ https://www.ncbi.nlm.nih.gov/pubmed/35519073 http://dx.doi.org/10.1039/d0ra06970a

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