Lessons learned in engineering interrupted adenylation domains when attempting to create trifunctional enzymes from three independent monofunctional ones

Interrupted adenylation (A) domains are fascinating examples of multifunctional enzymes. They are found in nonribosomal peptide synthetases (NRPSs), which biosynthesize nonribosomal peptides (NRPs), a major class of medically relevant natural products (NPs). Interrupted A domains contain the catalyt...

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Detalles Bibliográficos
Autores principales: Lundy, Taylor A., Mori, Shogo, Garneau-Tsodikova, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056781/
https://www.ncbi.nlm.nih.gov/pubmed/35519055
http://dx.doi.org/10.1039/d0ra05490a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056781/
https://www.ncbi.nlm.nih.gov/pubmed/35519055
http://dx.doi.org/10.1039/d0ra05490a

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