Synthesis of siRNAs incorporated with cationic peptides R8G7 and R8A7 and the effect of the modifications on siRNA properties

Small interfering RNA (siRNA) can be used as an innovative next-generation drug. However, there are several challenges in the therapeutic application of siRNAs, including their low cell membrane permeability. In this study, we designed and synthesized siRNAs, incorporating the cationic peptides R8G7...

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Detalles Bibliográficos
Autores principales: Matsubara, Miho, Honda, Kenji, Ozaki, Koki, Kajino, Ryohei, Kakisawa, Yuri, Maeda, Yusuke, Ueno, Yoshihito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056854/
https://www.ncbi.nlm.nih.gov/pubmed/35514421
http://dx.doi.org/10.1039/d0ra05919f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056854/
https://www.ncbi.nlm.nih.gov/pubmed/35514421
http://dx.doi.org/10.1039/d0ra05919f

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