Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift

Upon aging, the function of the intestinal epithelium declines with a concomitant increase in aging-related diseases. ISCs play an important role in this process. It is known that ISC clonal dynamics follow a neutral drift model. However, it is not clear whether the drift model is still valid in age...

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Detalles Bibliográficos
Autores principales: Hageb, Ali, Thalheim, Torsten, Nattamai, Kalpana J, Möhrle, Bettina, Saçma, Mehmet, Sakk, Vadim, Thielecke, Lars, Cornils, Kerstin, Grandy, Carolin, Port, Fabian, Gottschalk, Kay-E, Mallm, Jan-Philipp, Glauche, Ingmar, Galle, Jörg, Mulaw, Medhanie A, Geiger, Hartmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057243/
https://www.ncbi.nlm.nih.gov/pubmed/35487692
http://dx.doi.org/10.26508/lsa.202201408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057243/
https://www.ncbi.nlm.nih.gov/pubmed/35487692
http://dx.doi.org/10.26508/lsa.202201408

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