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Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift

Upon aging, the function of the intestinal epithelium declines with a concomitant increase in aging-related diseases. ISCs play an important role in this process. It is known that ISC clonal dynamics follow a neutral drift model. However, it is not clear whether the drift model is still valid in age...

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Detalles Bibliográficos
Autores principales:	Hageb, Ali, Thalheim, Torsten, Nattamai, Kalpana J, Möhrle, Bettina, Saçma, Mehmet, Sakk, Vadim, Thielecke, Lars, Cornils, Kerstin, Grandy, Carolin, Port, Fabian, Gottschalk, Kay-E, Mallm, Jan-Philipp, Glauche, Ingmar, Galle, Jörg, Mulaw, Medhanie A, Geiger, Hartmut
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057243/ https://www.ncbi.nlm.nih.gov/pubmed/35487692 http://dx.doi.org/10.26508/lsa.202201408

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