Vilsmeier reagent, NaHSe and diclofenac acid chloride: one-pot synthesis of a novel selenoindolinone with potent anticancer activity

An effective and straightforward synthesis of 3-seleno functionalized indolinone (5) involving Vilsmeier reagent is presented. Likewise, a procedure to achieve lactamization of diclofenac with excellent yields by using hydrides is also ascertained. Compound 5 exhibited impressive growth inhibition i...

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Detalles Bibliográficos
Autores principales: Ruberte, Ana Carolina, Aydillo, Carlos, Sharma, Arun K., Sanmartín, Carmen, Plano, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057275/
https://www.ncbi.nlm.nih.gov/pubmed/35517563
http://dx.doi.org/10.1039/d0ra07332f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057275/
https://www.ncbi.nlm.nih.gov/pubmed/35517563
http://dx.doi.org/10.1039/d0ra07332f

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