Vilsmeier reagent, NaHSe and diclofenac acid chloride: one-pot synthesis of a novel selenoindolinone with potent anticancer activity

An effective and straightforward synthesis of 3-seleno functionalized indolinone (5) involving Vilsmeier reagent is presented. Likewise, a procedure to achieve lactamization of diclofenac with excellent yields by using hydrides is also ascertained. Compound 5 exhibited impressive growth inhibition i...

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Detalles Bibliográficos
Autores principales: Ruberte, Ana Carolina, Aydillo, Carlos, Sharma, Arun K., Sanmartín, Carmen, Plano, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057275/
https://www.ncbi.nlm.nih.gov/pubmed/35517563
http://dx.doi.org/10.1039/d0ra07332f
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author Ruberte, Ana Carolina
Aydillo, Carlos
Sharma, Arun K.
Sanmartín, Carmen
Plano, Daniel
author_facet Ruberte, Ana Carolina
Aydillo, Carlos
Sharma, Arun K.
Sanmartín, Carmen
Plano, Daniel
author_sort Ruberte, Ana Carolina
collection PubMed
description An effective and straightforward synthesis of 3-seleno functionalized indolinone (5) involving Vilsmeier reagent is presented. Likewise, a procedure to achieve lactamization of diclofenac with excellent yields by using hydrides is also ascertained. Compound 5 exhibited impressive growth inhibition in most of the cell lines in an NCI-60 panel, particularly towards resistant breast cancer cells.
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spelling pubmed-90572752022-05-04 Vilsmeier reagent, NaHSe and diclofenac acid chloride: one-pot synthesis of a novel selenoindolinone with potent anticancer activity Ruberte, Ana Carolina Aydillo, Carlos Sharma, Arun K. Sanmartín, Carmen Plano, Daniel RSC Adv Chemistry An effective and straightforward synthesis of 3-seleno functionalized indolinone (5) involving Vilsmeier reagent is presented. Likewise, a procedure to achieve lactamization of diclofenac with excellent yields by using hydrides is also ascertained. Compound 5 exhibited impressive growth inhibition in most of the cell lines in an NCI-60 panel, particularly towards resistant breast cancer cells. The Royal Society of Chemistry 2020-10-19 /pmc/articles/PMC9057275/ /pubmed/35517563 http://dx.doi.org/10.1039/d0ra07332f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Ruberte, Ana Carolina
Aydillo, Carlos
Sharma, Arun K.
Sanmartín, Carmen
Plano, Daniel
Vilsmeier reagent, NaHSe and diclofenac acid chloride: one-pot synthesis of a novel selenoindolinone with potent anticancer activity
title Vilsmeier reagent, NaHSe and diclofenac acid chloride: one-pot synthesis of a novel selenoindolinone with potent anticancer activity
title_full Vilsmeier reagent, NaHSe and diclofenac acid chloride: one-pot synthesis of a novel selenoindolinone with potent anticancer activity
title_fullStr Vilsmeier reagent, NaHSe and diclofenac acid chloride: one-pot synthesis of a novel selenoindolinone with potent anticancer activity
title_full_unstemmed Vilsmeier reagent, NaHSe and diclofenac acid chloride: one-pot synthesis of a novel selenoindolinone with potent anticancer activity
title_short Vilsmeier reagent, NaHSe and diclofenac acid chloride: one-pot synthesis of a novel selenoindolinone with potent anticancer activity
title_sort vilsmeier reagent, nahse and diclofenac acid chloride: one-pot synthesis of a novel selenoindolinone with potent anticancer activity
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057275/
https://www.ncbi.nlm.nih.gov/pubmed/35517563
http://dx.doi.org/10.1039/d0ra07332f
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