More than one way to bind to cholesterol: atypical variants of membrane-binding domain of perfringolysin O selected by ribosome display

Herein, we report a high-throughput approach for the selection of peripheral protein domains that bind specifically to cholesterol in lipid membranes. We discovered variants of perfringolysin O, with non-conserved amino acid substitutions at regions crucial for cholesterol recognition, demonstrating...

Descripción completa

Detalles Bibliográficos
Autores principales: Šakanović, Aleksandra, Kranjc, Nace, Omersa, Neža, Podobnik, Marjetka, Anderluh, Gregor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057304/
https://www.ncbi.nlm.nih.gov/pubmed/35517550
http://dx.doi.org/10.1039/d0ra06976k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057304/
https://www.ncbi.nlm.nih.gov/pubmed/35517550
http://dx.doi.org/10.1039/d0ra06976k

Ejemplares similares