Controllable stripping of radiolabeled group in vivo to optimize nuclear imaging via NO-responsive bioorthogonal cleavage reaction

A novel “turn-off” strategy for controllable radionuclide clearance is established. 1,4-dihydropyridine (DHP) is used as a conditional linker to connect a radioisotope labeled moiety and nano-agent. A highly specific, sensitive and effective C–C bond cleavage of DHP happens in vivo when treated with...

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Detalles Bibliográficos
Autores principales: Li, Hua, Huang, Lumei, Jiang, Hailong, Fang, Jianyang, Guo, Zhide, Gao, Fei, Chen, Mei, Xu, Duo, Li, Zijing, Zhang, Xianzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057491/
https://www.ncbi.nlm.nih.gov/pubmed/35520872
http://dx.doi.org/10.1039/d0ra07186b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057491/
https://www.ncbi.nlm.nih.gov/pubmed/35520872
http://dx.doi.org/10.1039/d0ra07186b

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