Combinatorial targeting of Hippo-STRIPAK and PARP elicits synthetic lethality in gastrointestinal cancers

The striatin-interacting phosphatase and kinase (STRIPAK) complexes integrate extracellular stimuli that result in intracellular activities. Previously, we discovered that STRIPAK is a key machinery responsible for loss of the Hippo tumor suppressor signal in cancer. Here, we identified the Hippo-ST...

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Detalles Bibliográficos
Autores principales: An, Liwei, Cao, Zhifa, Nie, Pingping, Zhang, Hui, Tong, Zhenzhu, Chen, Fan, Tang, Yang, Han, Yi, Wang, Wenjia, Zhao, Zhangting, Zhao, Qingya, Yang, Yuqin, Xu, Yuanzhi, Fang, Gemin, Shi, Lei, Xu, Huixiong, Ma, Haiqing, Jiao, Shi, Zhou, Zhaocai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057599/
https://www.ncbi.nlm.nih.gov/pubmed/35290241
http://dx.doi.org/10.1172/JCI155468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057599/
https://www.ncbi.nlm.nih.gov/pubmed/35290241
http://dx.doi.org/10.1172/JCI155468

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