The Ca(2+)-gated channel TMEM16A amplifies capillary pericyte contraction and reduces cerebral blood flow after ischemia

Pericyte-mediated capillary constriction decreases cerebral blood flow in stroke after an occluded artery is unblocked. The determinants of pericyte tone are poorly understood. We show that a small rise in cytoplasmic Ca(2+) concentration ([Ca(2+)](i)) in pericytes activated chloride efflux through...

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Detalles Bibliográficos
Autores principales: Korte, Nils, Ilkan, Zeki, Pearson, Claire L., Pfeiffer, Thomas, Singhal, Prabhav, Rock, Jason R., Sethi, Huma, Gill, Dipender, Attwell, David, Tammaro, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057602/
https://www.ncbi.nlm.nih.gov/pubmed/35316222
http://dx.doi.org/10.1172/JCI154118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057602/
https://www.ncbi.nlm.nih.gov/pubmed/35316222
http://dx.doi.org/10.1172/JCI154118

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