PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma

The synthesis of serine from glucose is a key metabolic pathway supporting cellular proliferation in healthy and malignant cells. Despite this, the role that this aspect of metabolism plays in germinal center biology and pathology is not known. Here, we performed a comprehensive characterization of...

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Detalles Bibliográficos
Autores principales: D’Avola, Annalisa, Legrave, Nathalie, Tajan, Mylène, Chakravarty, Probir, Shearer, Ryan L., King, Hamish W., Kluckova, Katarina, Cheung, Eric C., Clear, Andrew J., Gunawan, Arief S., Zhang, Lingling, James, Louisa K., MacRae, James I., Gribben, John G., Calado, Dinis P., Vousden, Karen H., Riches, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057607/
https://www.ncbi.nlm.nih.gov/pubmed/35316216
http://dx.doi.org/10.1172/JCI153436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057607/
https://www.ncbi.nlm.nih.gov/pubmed/35316216
http://dx.doi.org/10.1172/JCI153436

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