Rubicon promotes rather than restricts murine lupus and is not required for LC3-associated phagocytosis

NADPH oxidase deficiency exacerbates lupus in murine models and patients, but the mechanisms remain unknown. It is hypothesized that NADPH oxidase suppresses autoimmunity by facilitating dead cell clearance via LC3-associated phagocytosis (LAP). The absence of LAP reportedly causes an autoinflammato...

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Detalles Bibliográficos
Autores principales: Gordon, Rachael A., Giannouli, Christina, Raparia, Chirag, Bastacky, Sheldon I., Marinov, Anthony, Hawse, William, Cattley, Richard, Tilstra, Jeremy S., Campbell, Allison M., Nickerson, Kevin M., Davidson, Anne, Shlomchik, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057630/
https://www.ncbi.nlm.nih.gov/pubmed/35192551
http://dx.doi.org/10.1172/jci.insight.155537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057630/
https://www.ncbi.nlm.nih.gov/pubmed/35192551
http://dx.doi.org/10.1172/jci.insight.155537

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