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The oxazolomycin family: a review of current knowledge

Oxazolomycin A and neooxazolomycin were firstly isolated in 1985 by the group of Uemura et al. from the Streptomyces sp. bacteria. To date, there have been reported 15 different natural compounds commonly classified as part of the oxazolomycin family. All oxazolomycin compounds possess extraordinary...

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Autores principales: Oleksak, Patrik, Gonda, Jozef, Nepovimova, Eugenie, Kuca, Kamil, Musilek, Kamil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057759/
https://www.ncbi.nlm.nih.gov/pubmed/35519217
http://dx.doi.org/10.1039/d0ra08396h
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author Oleksak, Patrik
Gonda, Jozef
Nepovimova, Eugenie
Kuca, Kamil
Musilek, Kamil
author_facet Oleksak, Patrik
Gonda, Jozef
Nepovimova, Eugenie
Kuca, Kamil
Musilek, Kamil
author_sort Oleksak, Patrik
collection PubMed
description Oxazolomycin A and neooxazolomycin were firstly isolated in 1985 by the group of Uemura et al. from the Streptomyces sp. bacteria. To date, there have been reported 15 different natural compounds commonly classified as part of the oxazolomycin family. All oxazolomycin compounds possess extraordinary structures and they represent a synthetic challenge. Such molecules are additionally known for their wide range of biological activity including antibacterial, antiviral and cytotoxic effects. The present review summarizes the structural elucidation and classification of oxazolomycin compounds, their biosynthesis and biological activity. It is further focused on the total syntheses of oxazolomycins and one formal synthesis reported to date.
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spelling pubmed-90577592022-05-04 The oxazolomycin family: a review of current knowledge Oleksak, Patrik Gonda, Jozef Nepovimova, Eugenie Kuca, Kamil Musilek, Kamil RSC Adv Chemistry Oxazolomycin A and neooxazolomycin were firstly isolated in 1985 by the group of Uemura et al. from the Streptomyces sp. bacteria. To date, there have been reported 15 different natural compounds commonly classified as part of the oxazolomycin family. All oxazolomycin compounds possess extraordinary structures and they represent a synthetic challenge. Such molecules are additionally known for their wide range of biological activity including antibacterial, antiviral and cytotoxic effects. The present review summarizes the structural elucidation and classification of oxazolomycin compounds, their biosynthesis and biological activity. It is further focused on the total syntheses of oxazolomycins and one formal synthesis reported to date. The Royal Society of Chemistry 2020-11-09 /pmc/articles/PMC9057759/ /pubmed/35519217 http://dx.doi.org/10.1039/d0ra08396h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Oleksak, Patrik
Gonda, Jozef
Nepovimova, Eugenie
Kuca, Kamil
Musilek, Kamil
The oxazolomycin family: a review of current knowledge
title The oxazolomycin family: a review of current knowledge
title_full The oxazolomycin family: a review of current knowledge
title_fullStr The oxazolomycin family: a review of current knowledge
title_full_unstemmed The oxazolomycin family: a review of current knowledge
title_short The oxazolomycin family: a review of current knowledge
title_sort oxazolomycin family: a review of current knowledge
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057759/
https://www.ncbi.nlm.nih.gov/pubmed/35519217
http://dx.doi.org/10.1039/d0ra08396h
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