Cargando…
The oxazolomycin family: a review of current knowledge
Oxazolomycin A and neooxazolomycin were firstly isolated in 1985 by the group of Uemura et al. from the Streptomyces sp. bacteria. To date, there have been reported 15 different natural compounds commonly classified as part of the oxazolomycin family. All oxazolomycin compounds possess extraordinary...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057759/ https://www.ncbi.nlm.nih.gov/pubmed/35519217 http://dx.doi.org/10.1039/d0ra08396h |
_version_ | 1784697972845445120 |
---|---|
author | Oleksak, Patrik Gonda, Jozef Nepovimova, Eugenie Kuca, Kamil Musilek, Kamil |
author_facet | Oleksak, Patrik Gonda, Jozef Nepovimova, Eugenie Kuca, Kamil Musilek, Kamil |
author_sort | Oleksak, Patrik |
collection | PubMed |
description | Oxazolomycin A and neooxazolomycin were firstly isolated in 1985 by the group of Uemura et al. from the Streptomyces sp. bacteria. To date, there have been reported 15 different natural compounds commonly classified as part of the oxazolomycin family. All oxazolomycin compounds possess extraordinary structures and they represent a synthetic challenge. Such molecules are additionally known for their wide range of biological activity including antibacterial, antiviral and cytotoxic effects. The present review summarizes the structural elucidation and classification of oxazolomycin compounds, their biosynthesis and biological activity. It is further focused on the total syntheses of oxazolomycins and one formal synthesis reported to date. |
format | Online Article Text |
id | pubmed-9057759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90577592022-05-04 The oxazolomycin family: a review of current knowledge Oleksak, Patrik Gonda, Jozef Nepovimova, Eugenie Kuca, Kamil Musilek, Kamil RSC Adv Chemistry Oxazolomycin A and neooxazolomycin were firstly isolated in 1985 by the group of Uemura et al. from the Streptomyces sp. bacteria. To date, there have been reported 15 different natural compounds commonly classified as part of the oxazolomycin family. All oxazolomycin compounds possess extraordinary structures and they represent a synthetic challenge. Such molecules are additionally known for their wide range of biological activity including antibacterial, antiviral and cytotoxic effects. The present review summarizes the structural elucidation and classification of oxazolomycin compounds, their biosynthesis and biological activity. It is further focused on the total syntheses of oxazolomycins and one formal synthesis reported to date. The Royal Society of Chemistry 2020-11-09 /pmc/articles/PMC9057759/ /pubmed/35519217 http://dx.doi.org/10.1039/d0ra08396h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Oleksak, Patrik Gonda, Jozef Nepovimova, Eugenie Kuca, Kamil Musilek, Kamil The oxazolomycin family: a review of current knowledge |
title | The oxazolomycin family: a review of current knowledge |
title_full | The oxazolomycin family: a review of current knowledge |
title_fullStr | The oxazolomycin family: a review of current knowledge |
title_full_unstemmed | The oxazolomycin family: a review of current knowledge |
title_short | The oxazolomycin family: a review of current knowledge |
title_sort | oxazolomycin family: a review of current knowledge |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057759/ https://www.ncbi.nlm.nih.gov/pubmed/35519217 http://dx.doi.org/10.1039/d0ra08396h |
work_keys_str_mv | AT oleksakpatrik theoxazolomycinfamilyareviewofcurrentknowledge AT gondajozef theoxazolomycinfamilyareviewofcurrentknowledge AT nepovimovaeugenie theoxazolomycinfamilyareviewofcurrentknowledge AT kucakamil theoxazolomycinfamilyareviewofcurrentknowledge AT musilekkamil theoxazolomycinfamilyareviewofcurrentknowledge AT oleksakpatrik oxazolomycinfamilyareviewofcurrentknowledge AT gondajozef oxazolomycinfamilyareviewofcurrentknowledge AT nepovimovaeugenie oxazolomycinfamilyareviewofcurrentknowledge AT kucakamil oxazolomycinfamilyareviewofcurrentknowledge AT musilekkamil oxazolomycinfamilyareviewofcurrentknowledge |