Synthesis of new thienylpicolinamidine derivatives and possible mechanisms of antiproliferative activity

Three thienylpicolinamidine derivatives 4a–c were prepared from their corresponding picolinonitriles 3a–c on treatment with lithium trimethylsilylamide, LiN(TMS)(2), followed by a de-protection step using ethanol/HCl (gas). DFT calculations were used to optimize the geometric structure of the newly...

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Detalles Bibliográficos
Autores principales: Ismail, Mohamed A., Abdel-Rhman, Mohamed H., Abdelwahab, Ghada A., Hamama, Wafaa S., El-Shafeai, Heba M., El-Sayed, Wael M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057764/
https://www.ncbi.nlm.nih.gov/pubmed/35519193
http://dx.doi.org/10.1039/d0ra08796c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057764/
https://www.ncbi.nlm.nih.gov/pubmed/35519193
http://dx.doi.org/10.1039/d0ra08796c

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