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Synthesis of new thienylpicolinamidine derivatives and possible mechanisms of antiproliferative activity
Three thienylpicolinamidine derivatives 4a–c were prepared from their corresponding picolinonitriles 3a–c on treatment with lithium trimethylsilylamide, LiN(TMS)(2), followed by a de-protection step using ethanol/HCl (gas). DFT calculations were used to optimize the geometric structure of the newly...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057764/ https://www.ncbi.nlm.nih.gov/pubmed/35519193 http://dx.doi.org/10.1039/d0ra08796c |