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The effect of alcohols as vehicles on the percutaneous absorption and skin retention of ibuprofen modified with l-valine alkyl esters

The effect of various alcohols as vehicles on skin permeability was compared for unmodified ibuprofen (IBU) and ion pairs of ibuprofen with l-valine alkyl esters [ValOR][IBU], in which the alkyl chain R was changed from C1 to C8. In vitro permeation experiments were conducted in a Franz cell with po...

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Detalles Bibliográficos
Autores principales: Ossowicz, Paula, Klebeko, Joanna, Janus, Ewa, Nowak, Anna, Duchnik, Wiktoria, Kucharski, Łukasz, Klimowicz, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057780/
https://www.ncbi.nlm.nih.gov/pubmed/35516534
http://dx.doi.org/10.1039/d0ra06567f