Enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives

A mild and efficient enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives was established, which is compatible with a broad range of substrates and delivers the final products in excellent yields (up to 99%) and ee values (up to 99%) with low catalyst loading (down to 1 mol...

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Detalles Bibliográficos
Autores principales: Cheng, Cheng, Li, Ying-Xian, Jia, Xue-Min, Zhang, Ji-Quan, Zhao, Yong-Long, Feng, Wei, Tang, Lei, Yang, Yuan-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058008/
https://www.ncbi.nlm.nih.gov/pubmed/35514906
http://dx.doi.org/10.1039/d0ra07806a
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author Cheng, Cheng
Li, Ying-Xian
Jia, Xue-Min
Zhang, Ji-Quan
Zhao, Yong-Long
Feng, Wei
Tang, Lei
Yang, Yuan-Yong
author_facet Cheng, Cheng
Li, Ying-Xian
Jia, Xue-Min
Zhang, Ji-Quan
Zhao, Yong-Long
Feng, Wei
Tang, Lei
Yang, Yuan-Yong
author_sort Cheng, Cheng
collection PubMed
description A mild and efficient enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives was established, which is compatible with a broad range of substrates and delivers the final products in excellent yields (up to 99%) and ee values (up to 99%) with low catalyst loading (down to 1 mol%). The synthetic potential of this methodology was also demonstrated in the gram scale level.
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spelling pubmed-90580082022-05-04 Enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives Cheng, Cheng Li, Ying-Xian Jia, Xue-Min Zhang, Ji-Quan Zhao, Yong-Long Feng, Wei Tang, Lei Yang, Yuan-Yong RSC Adv Chemistry A mild and efficient enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives was established, which is compatible with a broad range of substrates and delivers the final products in excellent yields (up to 99%) and ee values (up to 99%) with low catalyst loading (down to 1 mol%). The synthetic potential of this methodology was also demonstrated in the gram scale level. The Royal Society of Chemistry 2020-11-25 /pmc/articles/PMC9058008/ /pubmed/35514906 http://dx.doi.org/10.1039/d0ra07806a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Cheng, Cheng
Li, Ying-Xian
Jia, Xue-Min
Zhang, Ji-Quan
Zhao, Yong-Long
Feng, Wei
Tang, Lei
Yang, Yuan-Yong
Enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives
title Enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives
title_full Enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives
title_fullStr Enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives
title_full_unstemmed Enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives
title_short Enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives
title_sort enantioselective amination of 4-alkylisoquinoline-1,3(2h,4h)-dione derivatives
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058008/
https://www.ncbi.nlm.nih.gov/pubmed/35514906
http://dx.doi.org/10.1039/d0ra07806a
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