Enzymatic assembly of the salinosporamide γ-lactam-β-lactone anticancer warhead

The marine microbial natural product salinosporamide A (Marizomib) is a potent proteasome inhibitor currently in clinical trials for the treatment of brain cancer. Salinosporamide A is characterized by a complex and densely functionalized [Formula: see text]-lactam- [Formula: see text]-lactone bicyc...

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Detalles Bibliográficos
Autores principales: Bauman, Katherine D., Shende, Vikram V., Chen, Percival Yang-Ting, Trivella, Daniela B. B., Gulder, Tobias A. M., Vellalath, Sreekumar, Romo, Daniel, Moore, Bradley S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058210/
https://www.ncbi.nlm.nih.gov/pubmed/35314816
http://dx.doi.org/10.1038/s41589-022-00993-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058210/
https://www.ncbi.nlm.nih.gov/pubmed/35314816
http://dx.doi.org/10.1038/s41589-022-00993-w

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