H3K9me3 represses G6PD expression to suppress the pentose phosphate pathway and ROS production to promote human mesothelioma growth

The role of glucose-6-phosphate dehydrogenase (G6PD) in human cancer is incompletely understood. In a metabolite screening, we observed that inhibition of H3K9 methylation suppressed aerobic glycolysis and enhances the PPP in human mesothelioma cells. Genome-wide screening identified G6PD as an H3K9...

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Detalles Bibliográficos
Autores principales: Lu, Chunwan, Yang, Dafeng, Klement, John D., Colson, Yolonda L, Oberlies, Nicholas H., Pearce, Cedric J., Colby, Aaron H., Grinstaff, Mark W., Liu, Zhuoqi, Shi, Huidong, Ding, Han-Fei, Liu, Kebin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058223/
https://www.ncbi.nlm.nih.gov/pubmed/35351997
http://dx.doi.org/10.1038/s41388-022-02283-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058223/
https://www.ncbi.nlm.nih.gov/pubmed/35351997
http://dx.doi.org/10.1038/s41388-022-02283-0

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