Cargando…

H3K9me3 represses G6PD expression to suppress the pentose phosphate pathway and ROS production to promote human mesothelioma growth

The role of glucose-6-phosphate dehydrogenase (G6PD) in human cancer is incompletely understood. In a metabolite screening, we observed that inhibition of H3K9 methylation suppressed aerobic glycolysis and enhances the PPP in human mesothelioma cells. Genome-wide screening identified G6PD as an H3K9...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Chunwan, Yang, Dafeng, Klement, John D., Colson, Yolonda L, Oberlies, Nicholas H., Pearce, Cedric J., Colby, Aaron H., Grinstaff, Mark W., Liu, Zhuoqi, Shi, Huidong, Ding, Han-Fei, Liu, Kebin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058223/ https://www.ncbi.nlm.nih.gov/pubmed/35351997 http://dx.doi.org/10.1038/s41388-022-02283-0

Ejemplares similares

G6PD functions as a metabolic checkpoint to regulate granzyme B expression in tumor-specific cytotoxic T lymphocytes
por: Lu, Chunwan, et al.
Publicado: (2022)

Contrasting roles of H3K4me3 and H3K9me3 in regulation of apoptosis and gemcitabine resistance in human pancreatic cancer cells
por: Lu, Chunwan, et al.
Publicado: (2018)

WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape
por: Lu, Chunwan, et al.
Publicado: (2021)

Pilot-scale production of expansile nanoparticles: Practical methods for clinical scale-up
por: Colby, Aaron H., et al.
Publicado: (2021)

IRF8 Regulates Intrinsic Ferroptosis through Repressing p53 Expression to Maintain Tumor Cell Sensitivity to Cytotoxic T Lymphocytes
por: Poschel, Dakota B., et al.
Publicado: (2023)

Two-Step Delivery: Exploiting the Partition Coefficient Concept to Increase Intratumoral Paclitaxel Concentrations In vivo Using Responsive Nanoparticles
por: Colby, Aaron H., et al.
Publicado: (2016)

Osteopontin Blockade Immunotherapy Increases Cytotoxic T Lymphocyte Lytic Activity and Suppresses Colon Tumor Progression
por: Klement, John D., et al.
Publicado: (2021)

p50 suppresses cytotoxic T lymphocyte effector function to regulate tumor immune escape and response to immunotherapy
por: Lu, Chunwan, et al.
Publicado: (2020)

Synthesis of poly(1,2-glycerol carbonate)–paclitaxel conjugates and their utility as a single high-dose replacement for multi-dose treatment regimens in peritoneal cancer
por: Ekladious, Iriny, et al.
Publicado: (2017)

Restoring FAS Expression via Lipid-Encapsulated FAS DNA Nanoparticle Delivery Is Sufficient to Suppress Colon Tumor Growth In Vivo
por: Merting, Alyssa D., et al.
Publicado: (2022)

Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis
por: Ibrahim, Mohammed L., et al.
Publicado: (2018)

Breast Cancer Spheroids Reveal a Differential Cancer Stem Cell Response to Chemotherapeutic Treatment
por: Reynolds, Daniel S., et al.
Publicado: (2017)

Imparting Superhydrophobicity to Biodegradable Poly(lactide-co-glycolide) Electrospun Meshes
por: Kaplan, Jonah A., et al.
Publicado: (2014)

Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes
por: Lu, Chunwan, et al.
Publicado: (2019)

Meroterpenoids from Neosetophoma sp.: A Dioxa[4.3.3]propellane Ring System, Potent Cytotoxicity, and Prolific Expression
por: El-Elimat, Tamam, et al.
Publicado: (2019)

Boolean logic in synthetic biology and biomaterials: Towards living materials in mammalian cell therapeutics
por: Bressler, Eric M., et al.
Publicado: (2023)

Osteopontin: A Key Regulator of Tumor Progression and Immunomodulation
por: Moorman, Hannah R., et al.
Publicado: (2020)

The NF-κB p65 and p50 homodimer cooperate with IRF8 to activate iNOS transcription
por: Simon, Priscilla S., et al.
Publicado: (2015)

Arabinose-Induced Catabolite Repression as a Mechanism for Pentose Hierarchy Control in Clostridium acetobutylicum ATCC 824
por: Servinsky, Matthew D., et al.
Publicado: (2018)

The arabinose transporter MtLat-1 is involved in hemicellulase repression as a pentose transceptor in Myceliophthora thermophila
por: Gu, Shuying, et al.
Publicado: (2023)

Pentose Metabolism in Bacteria
por: Rose, Irwin A.
Publicado: (1963)

Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS
por: Zhu, Xiaoyang, et al.
Publicado: (2021)

CD133(+)CD24(lo) defines a 5-Fluorouracil-resistant colon cancer stem cell-like phenotype
por: Paschall, Amy V., et al.
Publicado: (2016)

Ginseng-derived nanoparticles inhibit lung cancer cell epithelial mesenchymal transition by repressing pentose phosphate pathway activity
por: Yang, Lan, et al.
Publicado: (2022)

Rpd3L HDAC links H3K4me3 to transcriptional repression memory
por: Lee, Bo Bae, et al.
Publicado: (2018)

H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK
por: Olcina, M M, et al.
Publicado: (2016)

5-Fluorouracil Suppresses Colon Tumor through Activating the p53-Fas Pathway to Sensitize Myeloid-Derived Suppressor Cells to FasL(+) Cytotoxic T Lymphocyte Cytotoxicity
por: Yang, Yingcui, et al.
Publicado: (2023)

Regulation of the pentose phosphate pathway in cancer
por: Jiang, Peng, et al.
Publicado: (2014)

The Entner-Doudoroff and Nonoxidative Pentose Phosphate Pathways Bypass Glycolysis and the Oxidative Pentose Phosphate Pathway in Ralstonia solanacearum
por: Jyoti, Poonam, et al.
Publicado: (2020)

Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes
por: Reddington, James P, et al.
Publicado: (2013)

H3K4me2 functions as a repressive epigenetic mark in plants
por: Liu, Yuhao, et al.
Publicado: (2019)

Genome Sequence of Thermophilic Bacillus licheniformis Strain 3F-3, an Efficient Pentose-Utilizing Producer of 2,3-Butanediol
por: Li, Lixiang, et al.
Publicado: (2014)

MIR143 Inhibits Steroidogenesis and Induces Apoptosis Repressed by H3K27me3 in Granulosa Cells
por: Zhong, Yuyi, et al.
Publicado: (2020)

Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development
por: Postlmayr, Andreas, et al.
Publicado: (2020)

Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration
por: Rodriguez-Rodriguez, P, et al.
Publicado: (2012)

Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway
por: Yamamoto, Takehiro, et al.
Publicado: (2014)

Inhibition of the Carcinogenic Properties of Urethane by Pentose Nucleotides
por: Cowen, P. N.
Publicado: (1949)

The Pentose Phosphate Pathway Regulates the Circadian Clock
por: Rey, Guillaume, et al.
Publicado: (2016)

The Genetic Requirements for Pentose Fermentation in Budding Yeast
por: Mittelman, Karin, et al.
Publicado: (2017)

The Role of the Pentose Phosphate Pathway in Diabetes and Cancer
por: Ge, Tongxin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ikijmlga138667qh0hbooqj8qh