Folic acid-sulfonamide conjugates as antibacterial agents: design, synthesis and molecular docking studies

Dihydrofolate reductase (DHFR) inhibitors, as antibacterial agents, contain pyrimidine, pteridine, and azine moieties among many other scaffolds. Folic acid (FA), with a pteridine ring and amine group, was used as our focus scaffold, which was then conjugated with sulfonamides to develop new conjuga...

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Detalles Bibliográficos
Autores principales: Shahzad, Shabnam, Qadir, Muhammad Abdul, Ahmed, Mahmood, Ahmad, Saghir, Khan, Muhammad Jadoon, Gulzar, Asad, Muddassar, Muhammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058261/
https://www.ncbi.nlm.nih.gov/pubmed/35514930
http://dx.doi.org/10.1039/d0ra09051d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058261/
https://www.ncbi.nlm.nih.gov/pubmed/35514930
http://dx.doi.org/10.1039/d0ra09051d

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