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A hybrid approach unveils drug repurposing candidates targeting an Alzheimer pathophysiology mechanism
The high number of failed pre-clinical and clinical studies for compounds targeting Alzheimer disease (AD) has demonstrated that there is a need to reassess existing strategies. Here, we pursue a holistic, mechanism-centric drug repurposing approach combining computational analytics and experimental...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058900/ https://www.ncbi.nlm.nih.gov/pubmed/35510183 http://dx.doi.org/10.1016/j.patter.2021.100433 |