Overcoming Paradoxical Kinase Priming by a Novel MNK1 Inhibitor

[Image: see text] Targeting the kinases MNK1 and MNK2 has emerged as a valuable strategy in oncology. However, most of the advanced inhibitors are acting in an adenosine triphosphate (ATP)-competitive mode, precluding the evaluation of different binding modes in preclinical settings. Using rational...

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Detalles Bibliográficos
Autores principales: Bou-Petit, Elisabeth, Hümmer, Stefan, Alarcon, Helena, Slobodnyuk, Konstantin, Cano-Galietero, Marta, Fuentes, Pedro, Guijarro, Pedro J., Muñoz, María José, Suarez-Cabrera, Leticia, Santamaria, Anna, Estrada-Tejedor, Roger, Borrell, José I., Ramón y Cajal, Santiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059116/
https://www.ncbi.nlm.nih.gov/pubmed/35417652
http://dx.doi.org/10.1021/acs.jmedchem.1c01941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059116/
https://www.ncbi.nlm.nih.gov/pubmed/35417652
http://dx.doi.org/10.1021/acs.jmedchem.1c01941

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