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Overcoming Paradoxical Kinase Priming by a Novel MNK1 Inhibitor
[Image: see text] Targeting the kinases MNK1 and MNK2 has emerged as a valuable strategy in oncology. However, most of the advanced inhibitors are acting in an adenosine triphosphate (ATP)-competitive mode, precluding the evaluation of different binding modes in preclinical settings. Using rational...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059116/ https://www.ncbi.nlm.nih.gov/pubmed/35417652 http://dx.doi.org/10.1021/acs.jmedchem.1c01941 |