On the Utility of Chemical Strategies to Improve Peptide Gut Stability

[Image: see text] Inherent susceptibility of peptides to enzymatic degradation in the gastrointestinal tract is a key bottleneck in oral peptide drug development. Here, we present a systematic analysis of (i) the gut stability of disulfide-rich peptide scaffolds, orally administered peptide therapeu...

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Detalles Bibliográficos
Autores principales: Kremsmayr, Thomas, Aljnabi, Aws, Blanco-Canosa, Juan B., Tran, Hue N. T., Emidio, Nayara Braga, Muttenthaler, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059125/
https://www.ncbi.nlm.nih.gov/pubmed/35420805
http://dx.doi.org/10.1021/acs.jmedchem.2c00094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059125/
https://www.ncbi.nlm.nih.gov/pubmed/35420805
http://dx.doi.org/10.1021/acs.jmedchem.2c00094

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